Casa de Mi Padre

Will Ferrell

Armando Alvarez

Mariann Gavelo

Esmeralda

Molly Shannon

Sheila

Gael García Bernal

Onza

Nick Offerman

Agent Parker

Efren Ramirez

Esteban

Genesis Rodriguez

Sonia

Diego Luna

Raul

Pedro Armendáriz Jr.

Miguel Ernesto Alvarez

Adrian Martinez

Manuel

Alejandro Patiño

Hector

Manuel Urrego

Officer Blancarto

Jerry Collins

DEA Agent #2

Luis Carazo

Young Miguel Ernesto

Sandra Echeverría

Miguel Ernesto's Wife

Elijah Velarde

Young Armando

Eduardo Ricard

Old Friend #1

Pedro López

Old Friend #2

James Victor

Old Friend #3

Dan Haggerty

Self

José Luis 'El Puma' Rodríguez

El Puma / Wedding Singer

Patty Guggenheim

Band Member #2

Gayle Hooker

Margarite

Thomas Rosales Jr.

Friend George

Armando Guerrero

Friend Guizman

Christina Aguilera

Singing Lips (uncredited)