Jeff Goldblum

Professor Brody

Elizabeth Perkins

Mrs. Brody

Alexander Pollock

Scotty Brody

Miriam Margolyes

Sophie the Castle Maid

Tobey Maguire

Lou the Beagle (voice)

Alec Baldwin

Butch (voice)

Sean Hayes

Mr. Tinkles (voice)

Susan Sarandon

Ivy (voice)

Joe Pantoliano

Peek (voice)

Michael Clarke Duncan

Sam (voice)

Jon Lovitz

Calico (voice)

Charlton Heston

The Mastiff (voice)

Glenn Ficarra

Russian Blue (voice)

Billy West

Ninja Cat #1 (voice)

John Michael Higgins

Ginger Kitten (voice)

Richard Steven Horvitz

Puppy in Barn (voice)

Frank Welker

Buddy (voice)

Frank C. Turner

The Farmer

Lauren K. Robek

Pie Mom (as Kirsten Robek)

Mar Andersons

Guard at Gate

Gillian Barber

Factory Receptionist

Carol Ann Susi

Sophie's Sister

Randi Kaplan

Sophie's Sister

Mary Bogue

Sophie's Sister

Alvin Sanders

Mason Employee

Mark Schooley

Mason Employee

Lou Bollo

Worker

Scott Nicholson

Worker

Trish Schill

Worker

Babe Dolan

Wife Passenger

Reg Glass

Truck Driver (as Reginald Glass)

Charles Andre

Truck Driver

Peggy Logan

Nurse

Alicia Michelle

Jogger

Pamela Perry

Yorkie Dog Owner

Victor Wilson

Doberman Drill Sergeant (voice)

Salome Jens

Collie at HQ (voice)

Danny Mann

Ninja Cat (voice)

Billy West

Ninja Cat (voice)

Paul Pape

Wolf Blitzer (voice)

Myron Natwick

Mr. Mason

Doris Chillcott

Mrs. Calvert

Frank Meschkuleit

Additional Performances (puppeteer)