Ryan Reynolds

Wade / Deadpool

Morena Baccarin

Vanessa

Ed Skrein

Ajax

T.J. Miller

Weasel

Gina Carano

Angel Dust

Leslie Uggams

Blind Al

Brianna Hildebrand

Negasonic Teenage Warhead

Stefan Kapičić

Colossus (voice)

Karan Soni

Dopinder

Randal Reeder

Buck

Michael Benyaer

Warlord

Style Dayne

Jeremy (Pizza Guy)

Kyle Cassie

Gavin Merchant

Taylor Hickson

Meghan Orlovsky

Ayzee

Teen Girl #1

Naika Toussaint

Teen Girl #2

Isaac C. Singleton, Jr.

Boothe

Justyn Shippelt

Arcade Ticket Taker

Donna Yamamoto

Oncologist

Jed Rees

Recruiter

Hugh Scott

David Cunningham

Cindy Piper

Chinatown Merchant

Em Haine

Whisper Girlfriend

Aatash Amir

Whisper Boyfriend

Chad Riley

Pool Hall Goon

Paul Belsito

Fight Club Boss

Darcey Johnson

Garbage Truck Driver

Kyle Rideout

Super Soldier #1

Jason William Day

Super Soldier #2

Stan Lee

Strip Club DJ

Benjamin Wilkinson

No5 Orange Manager

Rachel Sheen

Strip Club Worker

Paul Lazenby

Flight Deck Guard

Rob Hayter

Bob

Andre Tricoteux

On-Set Colossus (uncredited)

Victoria De Mare

Stripper (uncredited)

Heather Ashley Chase

Stripclub Pole Performer (uncredited)

Kayla Adams

Waitress Kelly (uncredited)

Olesia Shewchuk

Guadalajaran Mother (uncredited)

Fabiola Colmenero

Guadalajaran Nurse (uncredited)

Colleen Bradford

Bar Patron (uncredited)

John Dryden

Thug #2 (uncredited)

David Hardware

Strip Club Spectator (uncredited)

Tony Chris Kazoleas

Fight Club Spectator (uncredited)

Rob Liefeld

Liefeld (uncredited)

David Longworth

Elderly Man (uncredited)

Michael Neumeyer

Soldier #1 (uncredited)

Sean Quan

Ten-year-old Boy (uncredited)

Anthony J. Sacco

Thug #3 (uncredited)

David Santana

Biker in Strip Club (uncredited)

Bronwyne Sloley

Fight Club Spectator (uncredited)

Dan Zachary

Biker (uncredited)