Eddie Murphy

Dr. John Dolittle

Kristen Wilson

Lisa Dolittle

Kyla Pratt

Maya Dolittle

Raven-Symoné

Charisse Dolittle

Steve Zahn

Archie (voice)

Lisa Kudrow

Ava (voice)

James Avery

Eldon

Andy Richter

Eugene Wilson

Lil' Zane

Eric

Denise Dowse

Secretary

Elayn J. Taylor

Eldon's Wife

Kevin Pollak

Riley / Alligator

Victor Raider-Wexler

Judge B. Duff

Jeffrey Jones

Joe Potter

Mark Griffin

Logger / Nature Show Narrator

Ken Hudson Campbell

Animal Control Officer / Dog / Animal Groupie #3 / Forest Animal (voice)

Anne Stedman

Woman

Tommy Bush

Farmer

Adam Vernier

Farm Worker

Chris Marley

Yuppie Man

Shaun Robinson

Newscaster

Googy Gress

Bear Announcer

Lisa Marie Hugueley

Shamu Trainer

Steve Irwin

The Crocodile Hunter

Doug Seus

Klondike Dave Delivery Man

Louise Osbourne

Waitress

Brie Hill Arbaugh

Chihuahua Lady

E.J. Wessel

Guy Throwing Frisbee

Jacob Vargas

Pepito (voice)

Michael Rapaport

Joey the Raccoon (Voice)

Isaac Hayes

Possum (voice)

Andy Dick

Lennie the Weasel (voice)

Joey Lauren Adams

Squirrel (voice)

Maria Arcé

Fish (voice)

Melique Berger

Fish (voice)

David Cross

Dog / Animal Groupie #2 (voice)

David DeLuise

School Fish #2 (voice)

Trevor Denman

Horse Race Announcer (voice)

John DiMaggio

Seeing Eye Dog / Wassup Fish / Mouse (voice)

Georgia Engel

Giraffe (voice)

Mike Epps

Sonny (voice)

Jamie Kennedy

Bandit / Forest Animal / Animal Groupie #1 (voice)

Tom Kenny

Male Tortoise (voice)

Clyde Kusatsu

Bee (voice)

Cedric the Entertainer

Zoo Bear #1 (voice)

David L. Lander

Bird (voice)

Michael McKean

Bird (voice)

Tara Mercurio

Deer (voice)

Mandy Moore

Girl Bear Cub

Frankie Muniz

Boy Bear Cub (voice)

Bob Odenkirk

Animal Groupie #4 / Forest Animal / Dog (voice)

Phil Proctor

Drunk Monkey (voice)

Reni Santoni

Rat #2 (voice)

Richard C. Sarafian

God Beaver (voice)

Hal Sparks

School Fish #1 (voice)

Renée Taylor

Female Tortoise (voice)

John Witherspoon

Zoo Bear #2 (voice)

Keone Young

Bee (voice)

Lawrence Pressman

Governor of California (uncredited)

Norm Macdonald

Lucky (voice)

Crystal the Monkey

Drunk Monkey (uncredited)

Arnold Schwarzenegger

White Wolf (voice) (archive sound) (uncredited)

John Leguizamo

Rat #2 (voice, uncredited)

Tank the Bear

Archie