Adrien Brody

Psycho Ed

Matt Bush

Henry Burke

Sean Marquette

Travis Breaux

Colin Hanks

Brandon Ellis

Michael Chiklis

Dr. Leslie Gordon

Adhir Kalyan

Sebastian Saleem

Mykelti Williamson

Paranoid

Luis Chávez

Big Dave

Max Van Ville

Little Dave

Brett Kelly

Martin Gordon

George Back

Malcolm

Alicia Sixtos

Sharky Ovante

Andrew Wilson

Hippie Dude

Camille Mana

Dana

Erica Vittina Phillips

Tameka

Arcadiy Golubovich

Edwin Hunter

Julia Ling

Charlyne

Cody Longo

Chad

Mary Birdsong

Mrs. Gordon

Yeardley Smith

Computer Skills Teacher

Curtis Armstrong

Mr. Thompson

Alex Biats

Spelling Bee Rival

John Beard

Male News Desk Reporter

Barret Swatek

Female News Desk Reporter

Rhys Coiro

Vato

Wyatt Russell

Drug PSA Stoned Teenager

Mike Eshaq

Lead Terrorist

Heather Elizabeth Regan

Cheerleader who collides with Henry

Terri Lyn Rodriguez

Vivian

Robert Bailey Jr.

Jeffrey

Kelli Rasmus

Hippie Chick

Shirley Benyas

Older Female Donor

Wallace Bridges

African American Donor

Carl Harry Carlson

Donor #1

Randy Godwin

Donor #2

Mike Evans

Donor #3

Linda Boston

Head Nurse

Nadine Crocker

Emily Tooms

Clarence Smith

Chess Opponent

Ron Ayers

Stunned Lawn Bowler

Karl Murphy

Band Teacher

Rachel Quaintance

Angry Parent #1

Peter Tocco

Angry Parent #2

Mike Woods

Announcer

Kerry Birmingham

Female Reporter

Kevin Yon

Mr. Cavanaugh

Sammy A. Publes

Cook #1

Rene Santana

Cook #2

Billye Thompson

Cop #1

J. J. Soria

Rubin

David Herbst

School Security Guard

John O'Hurley

Drug PSA (voice)

John Stalberg Jr.

Grandpa Frodo - Ed's Frog (voice)

Heather Kleisner

Henry's Mom (voice)

D.B. Dickerson

Stoned High School Student (uncredited)

Sabrina Dungan

High School Student (uncredited)

Penny Gibbs

School Admin (uncredited)

Adam Lorenz

Dwayne Reynolds (uncredited)

Bill Lumbert

Concerned Parent (uncredited)

Misty Mills

Teacher (uncredited)

Jerry Reid

High School Student (uncredited)

Steven Sutherland

Academy Student (uncredited)

Joe Tinpan

Terrorist (uncredited)

Michael Vartan

Calculus Teacher (uncredited)

Kathi J. Moore

Librarian

Trey Livingston

Student (uncredited)