Sid Haig

Captain Spaulding

Bill Moseley

Otis B. Driftwood

Sheri Moon Zombie

Baby Firefly

Karen Black

Mother Firefly

Erin Daniels

Denise Willis

Chris Hardwick

Jerry Goldsmith

Rainn Wilson

Bill Hudley

Jennifer Jostyn

Mary Knowles

Tom Towles

Lieutenant George Wydell

Walton Goggins

Deputy Steve Naish

Matthew McGrory

Tiny Firefly

Robert Allen Mukes

Rufus 'RJ' Firefly Jr.

Dennis Fimple

Grandpa Hugo Firefly

Jake McKinnon

Rufus 'Earl' Firefly Sr.

Harrison Young

Don Willis

Irwin Keyes

Ravelli

Michael J. Pollard

Stucky

Chad Bannon

Killer Karl

William Bassett

Sheriff Frank Huston

David Reynolds

Richard 'Little Dick' Wick

Joe Dobbs III

Gerry Ober

Judith Drake

Skunk Ape Wife

Gregg Gibbs

Dr. Wolfenstein

Ken Johnson

Skunk Ape Husband

Irvin Mosley Jr.

Lewis Dover

Tom Towles

George Wydell

Walter Phelan

Dr. Satan

Rob Zombie

Dr. Wolfenstein's assistant (uncredited)