John Wayne

Captain Dooley

Lloyd Nolan

Captain Stutz

Walter Abel

Col. Fuller

James Arness

Mac McMullen

Andy Devine

Willie Moon

Allyn Joslyn

J.H. Handy

Jimmy Lydon

Murray, Dooley's navigator

Harry Carey Jr.

Ralph Hunt, Moon's co-pilot

Hal Baylor

Stankowski, Dooley's engineer

Sean McClory

Frank Lovatt, Dooley's co-pilot

Wally Cassell

D'Annunzia, Dooley's radioman

Gordon Jones

Walrus

Frank Fenton

Captain Turner

Robert Keys

Major Ditson

Sumner Getchell

Lieutenant Cord

Regis Toomey

Sergeant Harper

Paul Fix

Wally Miller

Jim Dugan

Gidley

George Chandler

Rene

Louis Jean Heydt

Fitch

Bob Steele

Wilson

Darryl Hickman

Swanson

Mike Connors

Gainer

Cass Gidley

Stannish

Herbert Anderson

Breezy

Anthony De Mario

Ogden

Ann Doran

Moon's Wife (uncredited)

Fess Parker

Fitch's Co-Pilot (uncredited)

William A. Wellman

Narrator (voice) (uncredited)

Dawn Bender

Murray's Wife

Carl Switzer

Sonny Hopper

Billy Lee Aimone

Boy (uncredited)