Danny Trejo

Machete

Mel Gibson

Voz

Demián Bichir

Mendez

Amber Heard

Miss San Antonio

Michelle Rodriguez

Luz

Sofía Vergara

Desdemona

Charlie Sheen

Mr. President

Lady Gaga

La Camaleón

Antonio Banderas

El Camaleón 4

Walton Goggins

El Camaleón 1

Cuba Gooding Jr.

El Camaleón 2

Vanessa Hudgens

Cereza

Alexa PenaVega

Killjoy

Marko Zaror

Zaror

Tom Savini

Osiris Amanpour

William Sadler

Sheriff Doakes

Julio Oscar Mechoso

Chepo

Callie Hernandez

Space Babe

Billy Blair

Billy Blair

Samuel Davis

Clebourne

Jason Christopher

Lieutenant Brass

David C. Heard

Doctor Villachez

Carlos Rodríguez

Messenger

Juan Zuani

Radio Announcer (voice)

Emmy Robbin

Pris

Jimmy Gonzales

Man in Bondage

Pablo Bracho

Bartender Carlos

Ashley Wood

Male Tourist

Patricia Vonne

Female Tourist

Vincent Fuentes

Cabrito Cook

Rick Delgado

Police Captain

Daniel Arellano

Elderly Attendant

Elle LaMont

Dollface

Eduardo Renteria

Doctor Goodbar

Pablo Esparza

Grasa

Robert Tamayo

Stuttering Tito

Felix Sabates

Doc Felix

Edgar Arreola

Estoban

Jorge A. Jimenez

Dying Cartel Guy

Alejandro Antonio

Boss of Mendez

Sam Medina

Cartel Leader

Crystal Martinez

Wife of Mendez

Electra Avellan

Nurse Mona

Elise Avellan

Nurse Lisa

Marci Madison

Nurse Fine

Corey Burton

Trailer Voice Guy (voice)

Elon Musk

Elon Musk

Jessica Alba

Sartana Rivera (uncredited)

J.J. Perry

Voz's Henchman (uncredited)

Alexander Rodnyansky

Radio Guest (uncredited)