Ben Stiller

Larry Daley

Amy Adams

Amelia Earhart / Tess

Owen Wilson

Jedediah Smith

Hank Azaria

Kahmunrah / The Thinker / Abe Lincoln

Robin Williams

Theodore Roosevelt

Christopher Guest

Ivan the Terrible

Alain Chabat

Napoleon Bonaparte

Steve Coogan

Octavius

Ricky Gervais

Dr. McPhee

Bill Hader

George Armstrong Custer

Jon Bernthal

Al Capone

Patrick Gallagher

Attila the Hun

Jake Cherry

Nicky Daley

Rami Malek

Ahkmenrah

Mizuo Peck

Sacajawea

Kerry van der Griend

Neanderthal #1

Matthew Harrison

Neanderthal #2

Rick Dobran

Neanderthal #3

Randy Lee

Hun #1

Darryl Quon

Hun #2

Gerald Wong

Hun #3

Paul Cheng

Hun #4

Jay Baruchel

Sailor Joey Motorola

Mindy Kaling

Docent

Keith Powell

Tuskegee Airman #1

Craig Robinson

Tuskegee Airman #2

Samuel Patrick Chu

Teenage Boy #1

Augustus Oicle

Teenage Boy #2

Kai James

Teenage Boy #3

Clint Howard

Air and Space Mission Control Tech #1

Matty Finochio

Air and Space Mission Control Tech #2

George Foreman

George Foreman

Josh Byer

Capone Gangster #1

Sophie Levy

Young Girl #1

Tess Levy

Young Girl #2

Christina Schild

'American Gothic' Woman

Robert Thurston

'American Gothic' Farmer

Alberta Mayne

Kissing Nurse

Clifton MaCabe Murray

Kissing Sailor

Caroll Spinney

Oscar the Grouch (voice)

Thomas Morley

Darth Vader

Dan Joffre

Town Car Driver

Dave Hospes

Astronaut

Regina Taufen

New York Reporter

Shawn Levy

Infomercial Father

Joe Jonas

Cherub #1 (voice)

Kevin Jonas

Cherub #2 (voice)

Nick Jonas

Cherub #3 (voice)

Eugene Levy

Albert Einstein (voice)

Brad Garrett

Easter Island Head (voice)

Ed Helms

Larry Daley's Assistant (uncredited)

Jonah Hill

Brundon the Security Guard (uncredited)

Thomas Lennon

Wilbur Wright (uncredited)

Crystal the Monkey

Dexter / Able (uncredited)

Frankie Jonas

Boy in Museum