E. G. Daily

Tommy Pickles (voice)

Nancy Cartwright

Chuckie Finster (voice)

Kath Soucie

Phil DeVille / Lil DeVille / Betty DeVille (voice)

Dionne Quan

Kimi Watanabe-Finster (voice)

Tim Curry

Nigel Thornberry (voice)

Joe Alaskey

Lou Pickles (voice)

Tress MacNeille

Charlotte Pickles (voice)

Michael Bell

Drew Pickles / Charles 'Chaz' Finster, Sr. (voice)

Julia Kato

Kira Watanabe-Finster (voice)

Phil Proctor

Howard DeVille (voice)

Jack Riley

Stuart 'Stu' Pickles (voice)

Tara Strong

Dil Pickles (voice)

Cree Summer

Susie Carmichael (voice)

Cheryl Chase

Angelica Pickels (voice)

Melanie Chartoff

Didi Pickles (voice)

Lacey Chabert

Eliza Thornberry (voice)

Danielle Harris

Debbie Thornberry (voice)

Jodi Carlisle

Marianne Thornberry (voice)

Flea

Donnie Thornberry (voice)

Tom Kane

Darwin (voice)

Bruce Willis

Spike (voice)

Tony Jay

Dr. Lipschitz (voice)

Ethan Phillips

Toa (voice)

Chrissie Hynde

Siri (voice)