Tobin Bell

Jigsaw / John

Costas Mandylor

Hoffman

Mark Rolston

Erickson

Betsy Russell

Jill

Shawnee Smith

Amanda

Peter Outerbridge

William

Athena Karkanis

Agent Perez

Samantha Lemole

Pamela Jenkins

Tanedra Howard

Simone

Marty Moreau

Eddie

Shawn Ahmed

Allen

Janelle Hutchison

Addy

Gerry Mendicino

Janitor

Caroline Cave

Debbie

George Newbern

Harold

Shauna Macdonald

Tara

Devon Bostick

Brent

Darius McCrary

Dave

Shawn Mathieson

Josh

Melanie Scrofano

Gena

Karen Cliche

Shelby

James Gilbert

Aaron

Larissa Gomes

Emily

Dan Duran

Newscaster

Billy Otis

Cecil

James Van Patten

Coroner

Jon Mack

Female Addict

Francois Sagat

Male Addict

Elle Downs

Clinic Nurse

Tenika Davis

Irate Clinic Woman

Karl Campbell

Security Guard

Ginger Ruriko Busch

Sachi

Jessie Rusu

Female Officer

Mpho Koaho

Tim

Chris Owens

Additional Voice Talent (voice)

Vickie Papavs

Additional Voice Talent (voice)

Catherine Rix

Additional Voice Talent (voice)

John Watson

Additional Voice Talent (voice)

Joris Jarsky

Seth (archive footage) (uncredited)

Angus Macfadyen

Jeff Denlon (archive footage) (uncredited)

Scott Patterson

Agent Strahm (archive footage) (uncredited)

Bahar Soomekh

Lynn (archive footage) (uncredited)

Niamh Wilson

Corbett (archive footage) (uncredited)