Freddie Prinze Jr.

Fred

Sarah Michelle Gellar

Daphne

Matthew Lillard

Shaggy

Linda Cardellini

Velma

Neil Fanning

Scooby Voice (voice)

Rowan Atkinson

Mondavarious

Isla Fisher

Mary Jane

Miguel A. Núñez Jr.

Voodoo Maestro

Steven Grives

N' Goo Tuana

Charles Stan Frazier

Sugar Ray

Craig Bullock

Sugar Ray

Matthew Murphy Karges

Sugar Ray

Mark McGrath

Sugar Ray

Rodney Sheppard

Sugar Ray

Sam Greco

Zarkos

Charlie Cousins

Velma's Friend

Kristian Schmid

Brad

Nicholas Hope

Old Man Smithers

Scott Innes

Scrappy Voice (voice)

J.P. Manoux

Scrappy Rex Voice (voice)

Chris Cruickshanks

Tiny Henchman

Alex Ruiz

Reporter #1

Sheryl Benko

Reporter #2

Rio Nugara

Island Emissary

David Vallon

Bartender Dead Mike's

Troy MacKinder

Guy in the Vat

Michala Banas

Carol

Holly Brisley

Training Video Woman

Robert Díaz

Training Video Guy #1

Remi Broadway

Training Video Guy #2

Martin Broome

Melvin Doo

Simone Dumbleton

Co-Ed

Jonathan Coffey

Fitzgibbon

Michael Caffery

Coast Guard #2

Kyas Sherriff

Airport Attendant

Celeste Gosnell

Airport Family

Bradley Gosnell

Airport Family

Cayley Gosnell

Airport Family

Audrey Gosnell

Airport Family

Kurt Duval

Spooky Hotel Bartender

Janis McGavin

Co-Ed Hottie

Emily Gosnell

Autograph Seeker

Marea Lambert Barker

Autograph Seeker

Kym Jackson

Autograph Seeker

Danielle Starkey

Autograph Seeker

Andrew Bryniarski

Cavern Henchman

Craig Behenna

Henchman #1

Keith S. Bullock

Henchman #2

Jess Harnell

Creature Voices (voice)

Frank Welker

Creature Voices (voice)

Pamela Anderson

Pamela Anderson (uncredited)